… chemistry are significant contributors to increased lipid peroxidation in a number of pathogenic
settings, deficiencies in the numerous defense systems … defense system components is …

… system xc – inhibitors, imidazole ketone erastin (IKE) is a potent, metabolically stable inhibitor
of system … and demonstrated that IKE exerted an antitumor effect by inhibiting system xc …

… A gravity-driven system (RSC-200, Bio-Logic) with freely rotating tubes was used for the
ligand perfusion. The bath and ligand solutions were delivered through separate tubes to …

… The most common cytochrome P450 enzyme system is composed of a shared nicotinamide
adenine dinucleotide phosphate (NADPH)-dependent oxidoreductase (POR) unit and …

… To confirm that growth on methanol indeed depends on formaldehyde oxidation via the
glutathione system, we deleted the endogenous gene encoding for S-(hydroxymethyl)…

… Targeted protein degradation (TPD) has emerged as an exciting new era in chemical biology
and drug discovery. PROteolysis TArgeting Chimera (PROTAC) technology targets cellular …

… Similarly, the dTAG system can be used to evaluate and validate the biological consequences
of PROTAC-mediated POI degradation without need for POI ligand development by …

… To quantitatively compare the two systems, we evaluated bulk parameters that correspond
to lipid order, diffusivity and membrane packing. Lipid order was assessed by calculating the …

… Moreover, we found that small molecules activating ferroptosis through system x c – inhibition
or GPX4 inhibition synergize with radiation to induce ferroptosis in several cancer types by …

… We also summarize chemical modulators that are currently available for triggering or blocking
autophagy-dependent ferroptosis and that may be developed for therapeutic interventions …